![]() ![]() Results of earlier quantitative studies of iron absorption, ferrokinetics, utilization, and storage of iron, obtained with tracer techniques using radioisotopes can also now be reinterpreted in the light of our new knowledge. Defining the molecular underpinnings of iron-related diseases has gone hand in hand with these molecular advances, and the new knowledge we have gained about iron has led to the recognition that the metal plays critical roles in a broad range of pathophysiological processes. Many new iron-related molecules have been described, our knowledge of how iron metabolism is regulated at both the cellular and systemic levels has expanded enormously, and we now have a far greater appreciation of the diversity of iron biology in different tissues. Molecular advances in our understanding of iron homeostasis over the last 20 years have revolutionized how we think about body iron intake, distribution, utilization, and storage. ![]() ![]() Iron is not only a crucial element for oxygen delivery in almost all living organisms, but also for the formation of toxic oxygen radicals that can lead to tissue damage if not controlled. ![]()
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January 2023
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